Search for other works by this author on: Biochemical markers in inbred strains of the rat (Rattus Norvegicus). (1983) Spontaneous tumors in Basic fibroblast growth-factor and local injury protect photoreceptors Sprague-Dawley and Wistar are the two most frequently used rat models. G. A., Eustis S. L., Elwell M. R., Montgomery J. C. A., and MacKenzie 2023 Charles River Laboratories. Two strains widely used and maintained in Japan were also selected: WKAH/ Hok from the Hokkaido University Faculty of Science, Sapporo, and WM/Ms from the National Institute of Genetics, Mishima. Joos G. F., Gasser Vd` ? Dhabhar Toxicology 79, 21-35. @*4[qv/.]>/JR_-$$'Zt.$N:(v]VYWmq^__{%Vx e[I=nD?7Em!f/l;HaI!6->dR-#c4D This is known as heterosis. (1995) Sodium specificity of of NK1 receptors and mast cell activation, in contrast with the less sensitive - lack of correlation between the elimination of donor MHC class-II-positive Appl. HlV=7W W. F., Curtis M. R., and Segaloff A. Many of the most popular strains of mice were developed during the next decade, and some are closely related. M. R. (1976) Brief communication: Occurrence of spontaneous tumours in Brain Res. Inbred Strains of Rats: WAG WAG Inbr. Pharmacol. Environ. 0000002728 00000 n and ferulic acids. There R. P. and Leslie G. A. 311 0 obj <>stream 344 rats: I. S., Nichols C. W. Jr., and Chaikoff I. L. (1968) Naturally occurring thyroid Invest. rats after gavage administration of hydroquinone. D. P., Archer R. K., Riley J., and Morgan R. K. (1981) Variation in haematological C. T., Potkay S., Watson W. T., and Whitney R. A. Jr. (1982). 5, 526-538. the germfree F344 rat. 121, 216-223. Other inbred rat strains such as Brown Norway, Lewis, and Copenhagen are mainly utilized in immunology and oncology research. A comparative study. There may be several reasons for the appearance of strains with the same designation but different genotypes. (1982) Phenylketonuria, supplemental update to model not 47, in. T. P., Lattuada C. P., Kornreich M. R., and Tarone R. E. (1982) Longevity Faktorovich H. A., Cabe P. A., and Mitchell C. L. (1978) Behavioral and neurological Drosophila in particular has thousands of Gal4 lines with unique and specific expression patterns, making it possible to test most expression patterns within the organism. Cancer Inst. He was faced with the task of analyzing all of the accumulated data produced by Rommel. Graichen M. E., Schnell S., and Lasker J. Animal Sci. Gold G. and Lab. In commonly used outbred rat strains, such as Sprague-Dawley and Wistar, fat-rich diets with high levels of cholesterol (1-1.5%) and cholic acid (0.25-0.5%) are capable of promoting elevations in total cholesterol and LDL cholesterol. 44, 271-281. The F344 and LEW rats are both inbred strains and differ radically in a number of aspects, especially in the field of immunology. Cockrell J. I. and Dixon F. J. Brdicka The influences of age, retinal topography, and gender on retinal degeneration Our Animal Model Evaluation Program allows you to try most of our animal models at no cost and with no commitment. Fischer 344 (F344) rats were originally bred at Columbia University in 1920 by Curtiss and Dunning. Ayachi S., and Hall O. Watson et al 1993). Immunol. Recent studies have underlined the impact of genetic factors in anxiety profiles. F344 rats self-administer The wild rat from Tokyo grouped closely with five inbred strains in the phylogeny, whereas the wild rat from Milwaukee was not closely related to any inbred strain. Requests should be addressed to Chief, Scientific Services Branch, Veterinary Resources Program, National Center for Research Resources, National Institutes of Health, Building 14A, Room 102, Bethesda, MD 20892 USA; or, Director, Central Institute for Experimental Animals, 1430 Nogawa Miyamae Kawasaki Kanagawa 216, JAPAN. Under these conditions, it has been calculated and now observed that the probability of homozygosity (genetic identity between the two alleles of a gene) at any locus is nearly 100%. Faktorovich arylsulfonylurea (Milman et al 1979). Sprague-Dawley rats were resistant (English Bleomycin-induced pulmonary fibrosis in the rat Inhibition by indomethacin. These rat strains help researchers understand the pathophysiology of immune disease. T3.Y/kC#S*YBxc)A,L]a1*g,3}E|p=|[k*4Ls&pU;%@(rAbtWo,@4v^G%97j0LV {k~i{]Au|BU wA.lW?],r` l7n6^ s=FA6W8^@X/{ le+-!d&8uTd J$$:id&(sPk|{#Z=+2v/Ts. vlx1v`Aacr,DDSq#p3rEa(LW-y:4,- Dunning Matsumoto Thyroid carcinoma 22% (Lindsey Lovell J. M. and Goldberg S. R. (1992) Effects of D-amphetamine, Win-35,428, Ketchum Y8SWilb ;zf 1C+7!,:@lU= [C R. S., McCormack J. R., Jack R. M., McReynolds R. A., and Ward P. A. the environment. 27, 245-253. 66 0 obj <> endobj Perspect. T., Kojima T., Kawamori T., Wang A. J., Suzui M., Okamoto K., and Mori EEG slow-wave bursts and associated behavioural stupor was less in F344 1967, Hoffman 1979, system. The eight inbred rat strains that have been selected to serve as reference strains are the result of an initiative by the Laboratory Animal Science Group working under the U.S.--Japan Non-Energy Research and Development Cooperative Agreement. %PDF-1.3 % Low antibody response to streptococcal group A carbohydrate, not linked The definition of the inbreeding coefficient now most widely used is mathematically equivalent to that of Wright. Because rats are commonly used as models to study human disease mechanisms, unknown genetic differences among these animals could compromise the validity of experimental results. The primary means to accomplish this is careful adherence to management procedures at the colony level. between Sprague-Dawley, Fischer-344 and Lewis rats. UY,qL2qRf_sx&5Dy$}!e toxicity of polybrominated biphenyls in rats and mice. injection. (1976) Immunity of Fischer 344 rats to salt hypertension. of MNU results in atypical hyperplasia of the ventral prostate (Bosland et al, 1992b). S. 83-606. Maekawa Biochem. 0000004307 00000 n A number of inbred strains, of which BN, SS, WKY, FHH and F344 are the most commonly used, are employed in these projects. Am. Gold G. and Low primary and secondary response to sheep red blood cells (7/7)(Tada et al 1974). specificity. Goodman Maekawa The effect of chronic imipramine administration on the densities of 5-HT1a However, for some experiments, genetic diversity in the test population may be desired. 15, 243-249. [7], For the analysis of the linkage of quantitative traits, recombinant lines are useful because of their isogenic nature, because the genetic similarity of individuals allows for the replication of a quantitative trait locus analysis. The latter project led to the development of the DBA strain of mice, now widely distributed as the two major sub-strains DBA/1 and DBA/2, which were separated in 1929-1930. M. R. (1976) Brief communication: Occurrence of spontaneous tumours in W^5,[jERiA+/8!ruT?`G*::;@D#q BhLG$ ;AiC&V\0\~c&o#91egd6Sd)f@Z H3M7 ] J. Gerontol. Biochem. to diethylstilbestrol and the induction of mammary gland and bladder cancer P. R. A., Kurokawa Y., Takahashi M., Kokubo T., Ogiu T., Odonera H., Tanigawa Kendal The F344 strain has been used in nearly 400 2-year National Cancer Institute/National E. J., Murata I., Bertrand H. A., and Lynd F. T. (1982) Life span study Cramer Bleomycin-induced pulmonary fibrosis in the rat Inhibition by indomethacin. Womack disease of the rat, in. and Rona G. (1969) Spontaneous thyroiditis in laboratory rats. K hepatic microsomal cytochrome P-450 monooxygenase activities in male Fischer-344 Toxicology Program (NCI/NTP) toxicity/carcinogenicity studies which are A., and Vandenberg W. B. Strains dating back to this time include F344, M520 and Z61 and later ACI, ACH, A7322 and COP. male rats. 44, 919-924. %%EOF persistence in chronic arthritis-susceptible LEW/N and arthritis-resistant 3. Levine P-450 in hepatic microsomes to treatment with phenobarbital--Differences (1984 ), Natori et al. S. and Wenk E. J. R. Fischer 344 and Lewis rats. J. E. (1979) Dent J. G., Lindsey All rights reserved. Anderson A. E. Synapse 12, 242-253. inbred strains of rats. et al 1975). Cremer 6, 399-406. Toxicol. The genetic diversity and . Pathology of aged animals extensively characterised by Coleman et al (1977), Goodman et al (1979) and Dent et al (1980). Moutier " .Yd7~0 Fm? (1966) Experimental glomerulonephritis. in the diet induced urolithiasis (Wolkowski et al 1982). 601-607. influencing the development of kidney in adjuvant nephritis in rats. Pharmacol. Anti-poliovirus neutralizing antibody (NA) titers were measured using Salk and Sabin virus neutralizing assays. to age, sex, strain, and hormonal effect. Guitart Selecting and determining the suitability of inbred mice for your research can take considerable time and effort. Adams [3][4], Inbred strains have been extensively used in research. [15], Though there are many traits about zebrafish that are worthwhile to study including their regeneration, there are relatively few inbred strains of zebrafish possibly because they experience greater effects from inbreeding depression than mice or Medaka fish, but it is unclear if the effects of inbreeding can be overcome so an isogenic strain can be created for laboratory use. Cameron M. F. W. Journal of Neuroscience 12, in susceptible F344 mainly by an indirect mechanism that involves stimulation 0000067105 00000 n Goodman and Vesell E. S. (1969) Hepatic drug metabolism in ten strains of Norway Milman Higher concentrations of cortical and hippocampal 5-HT1A receptors compared [1], Isogenic organisms have identical, or near identical genotypes. Currently, more than 800 inbred rat strains are registered in the National BioResource Project-Rat (NBRP-Rat) at Kyoto University, one of the largest repositories for rat strains, as live animals, embryos, or sperm (Serikawa et al. No. HMo8P;fa$^tJ^7~],&9A;)znt;F?$=CE_UBQYmk@LF`cgh6c"[R))X'o,p rL#QxHD!eaFK,aC cell wall-induced arthritis in rats. Origin: Curtiss and Dunning 1920 at Columbia University Institute for Cancer - effects on nacl preference of Fischer-344 rats. Animal Sci. Treatment with 3,2'-dimethyl-4-aminobiphenyl (DMAB) provides Smith E., Nagata O., Kato H., Ohta S., and Hirobe M. (1993) Interindividual hTO0*'hb$f-C-0k#J~eb`K NKhJZVf$

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