See your dentist regularly. This may help to protect healthy cells from damage. Prolia and Xgeva both contain the active drug denosumab, but they are not approved to treat all of the same conditions. For this reason, some calcium supplements are combined with vitamin D. This vitamin is available in two forms, vitamin D 2 (ergocalciferol) and vitamin Do not stop, skip or delay taking Prolia without first talking with your doctor. Store in the original container away from heat and light. Prolia is also available in a biosimilar form. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. So, your bones become weak and brittle. Prolia is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. Problem absorbing minerals. Learn more details about some of the side effects that Prolia may cause. When estrogen levels drop, your risk of osteoporosis goes up. And some of these side effects are more common with certain uses of Prolia. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. Its a, Forteos active ingredient is teriparatide. But if they become bothersome, talk with your doctor or pharmacist. If you cant properly absorb calcium or other minerals, be sure to talk with your doctor before using Prolia. The fractures may require surgeries, take several months to heal, or both. To see a side-by-side comparison of Prolia and Fosamax, view this drug article. Visit www.fda.gov/medwatch, orcall1-800-FDA-1088. Patients should not stop Prolia treatment without first consulting your * Sex and gender exist on spectrums. 2023 eHealthMe.com. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. While youre taking Prolia, your healthcare provider will also strongly suggest taking at least 1000 mg of calcium and 400 international units (IU) of vitamin D daily to prevent hypocalcemia or low calcium levels. The conditions and factors to consider include: Upcoming dental procedures. Low blood calcium level. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. Your risk for some health conditions increases when you are postmenopausal. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. pain in bones and muscles, including back, arm, and leg pain, pain or swelling in the thigh or groin area. See additional information. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. With arthritis, you have pain and inflammation of your joints. Use of the term female in this article refers to sex assigned at birth. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. WebYou should take calcium and vitamin D as your doctor tells you to while you receive If youre concerned about side effects with Prolia, talk with your doctor. They can also suggest ways to relieve this side effect. Like most drugs, Prolia may cause mild or serious side effects. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines What should I know about Prolia vs. Zometa? Side effects are possible with Prolia use, but in most cases they go away after a while. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing. What do I need to be aware of if I need a tooth extraction while Im using Prolia? But doing so can cause more bone breakdown and increase your risk for bone fractures. Forteo is given as a self-injection once daily. RA is an autoimmune condition in which your immune system attacks your joints. They can treat the infection as needed. Prolia is used in adults to treat osteoporosis or bone loss in people who: who cannot use another osteoporosis medicine or these medicines did not work well. You may report side effects to FDA at 1-800-FDA-1088. Vitamin D The body needs vitamin D to absorb calcium. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of You should not receive Prolia if you are allergic to denosumab, or if you But theyre each effective in treating osteoporosis and preventing bone loss. Prolia contains the active drug denosumab, while Tymlos contains the active drug abaloparatide. Doctors sometimes prescribe Prolia to treat osteoporosis and bone thinning. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. If youre breastfeeding, you should not receive Prolia. But they each work differently because Prolia is a monoclonal antibody (it may also be called a miscellaneous bone resorption agent) and Reclast is a bisphosphonate which means they have different side effects, other uses, tolerability, and effectiveness profiles. A special MedGuide will be given to you before each treatment. But if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. The drug stays in your system and continues to slow bone breakdown over this period of time. Cleveland Clinic is a non-profit academic medical center. If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. This increases your risk for bone fractures. They also include any added costs of the drug being given by a healthcare professional. Do not shake the prefilled syringe. Thyroid or parathyroid surgery. Continue reading, Prolia (denosumab) does increase bone density. Bisphosphonates, on the other hand, help increase bone thickness and prevent bone breakdown. It does the same thing that. Whats the Connection Between Estrogen and Osteoporosis? We avoid using tertiary references. Do not use denosumab if you are pregnant. Prolias manufacturer also provides some self-injection instructions, as well as a video to show you how to inject Prolia. It is often used in osteoporosis. So, dont be afraid to ask questions or offer feedback on your treatment. Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Your doctor will recommend the dosage of Prolia thats right for you. you can take. But hair loss has been reported by people who have taken Prolia since then. For a detailed breakdown of Prolia versus Xgeva, check out this article. Use of the terms female and male in this article refers to sex assigned at birth. Prolia is a monoclonal antibody. Xgeva is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks. may occur. If you have a male* sexual partner, they should use birth control during this time as well. Theyll discuss with you other treatments to help protect you from fractures and bone loss. This drug may decrease your body's ability to fight infection. A few examples of bisphosphonates include: If youd like to know more about using a bisphosphonate for your condition, talk with your doctor. * Sex and gender exist on spectrums. Lifestyle changes that can help improve cholesterol levels include exercising regularly and eating a healthy diet. Theyll discuss with you other treatments to help prevent bone loss. Before beginning treatment with Prolia, ask your doctor about the benefits and risks of the drug. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Other drugs may interact with denosumab, including prescription and over-the-counter medicines, vitamins, and herbal products. * In this article, we use the terms male and female to refer to someones sex assigned at birth. Will my fracture risk come back if I stop Prolia treatment? Common side effects of Prolia can vary depending on which condition the drug is being used to treat. Use effective birth control while using this medicine and for at least 5 months after your last dose. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. And theyll recommend if its the best option for your condition. Can you drink alcohol while taking Prolia? But before taking Prolia, be sure to tell your doctor about all medications you take (including prescription and over-the-counter types). It may also be higher if you have dental work done while youre taking Prolia. Its given to adults who are at high risk for bone fractures. You should also take calcium and vitamin D supplements while being Youll receive Prolia doses from a healthcare professional. Also, its important to brush and floss your teeth regularly while youre using Prolia. For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. Others may continue for as long as you take the drug, but they can be easily managed. eHealthMe is studying from 138,307 Prolia users for its effectiveness, alternative drugs and more. Be sure to talk with your doctor about which medication is right for you. Courtney Sullivan, Certified Yoga Instructor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT. (Chlorhexidine helps kill germs in your mouth.). Please see Prolia full You may want to know how Prolia compares to the medication Tymlos. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). You do not give Prolia to yourself. Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. Both are prescription medicines. We comply with the HONcode standard for trustworthy health information. If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. For more information, you can refer to the drugs prescribing information. Prolia is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments You should also ask your doctor if Prolia is safe for you if you have or have had: Additionally, let your doctor know if youre pregnant or breastfeeding. What should I know about Prolia vs. Tymlos? Its possible that some of Prolias side effects may be long term, but theyre rare. They may recommend ways to ease your symptoms and determine whether you should keep taking Prolia. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Get emergency medical help if you have signs of an allergic reaction to Prolia: hives, itching, rash; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat. 2,4. Calcium has active ingredients of calcium. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. You might wonder how Prolia and the drug Xgeva compare. Weakness and tingling can also occur. How long will I need to keep taking Prolia? If the user is trying to grow bone due to osteoporosis, osteopenia, or any reason, the recommended intake is 4 capsules divided into 2 doses also taken in the morning and evening with food. Not getting enough calcium in your diet can lead to fragile, brittle bones that are more prone to fractures and disease. If you have any questions about Prolias side effects, talk with your doctor. Some examples of these treatments include: Talk with your doctor about other drugs you may need to take with Prolia. You may need to have a negative pregnancy test before starting this treatment. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives. Another common osteoporosis medication is denosumab (Prolia, Xgeva). Since different people Do not become pregnant while taking this medicine or for 5 months after stopping it. Continue reading. It is advisable to take 2 capsules in the morning with food and 1 in the evening also with food. If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. Learn how estrogen affects bone health and how you can protect yourself from bone loss, Osteoporosis is more common in women than men, but it affects millions of men every year. In addition, your doctor will most likely recommend that you take calcium and vitamin D supplements while taking bisphosphonates, since vitamin D helps your body to absorb calcium. Certain side effects of Prolia that may last longer than others include: Ask your doctor about serious or long-lasting side effects of Prolia and what you should know before starting this drug. To learn about other mild side effects, talk with your doctor or pharmacist, or read Prolias medication guide. Keep in mind that Prolia is used to help strengthen your bones and prevent fractures, which may happen with falls. What should I know about Prolia vs. Boniva? And in my mind, that's no different than scheduling a visit to the dentist twice a year. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. This helps treat osteoporosis by improving bone mass and strengthening your bones. Youll likely receive Prolia long term if you and your doctor decide that the drug is effective and safe for you. If you plan to drink alcohol while using Prolia, ask your doctor how much is safe to drink. Learn about the highest quality calcium supplements here. With these reports, it wasnt known whether Prolia or something else (such as a different medication) caused the hair loss. Talk with your doctor about which other treatments are better choices for you. 1 shot every 6 months could mean fewer doses. Musculoskeletal pain refers to pain in your bones, muscles, tendons, and ligaments. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or; if you are pregnant. generic drugs) are not considered. Do not stop, skip or delay taking Prolia without first talking with your doctor. The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Tell your doctor if you become pregnant. They can help answer any questions you have about side effects from taking the drug. Be sure to talk with your doctor about your health history before you take Prolia. An allergic reaction is possible after using Prolia. Osteoporosis Is Common in Older Men, Know the Risks, Your Guide to Osteoporosis and Broken Bones: Know Your Risks, 7 Things You Can Do Today to Prevent Osteoporosis, treat osteoporosis in males* and in females* whove gone through, treat osteoporosis caused by long-term use of, increase bone mass in females using certain, increase bone mass in males using certain treatments for, increased risk of bone fracture after stopping Prolia treatment, such as having multiple, severe pain in your joints, bones, and muscles, skin-related side effects, such as rash, dry skin, or blisters, decreased bone production, which means your bones take longer to make new bone tissue, dental problems and jaw-related side effects*, jaw necrosis (death of tissue in the jawbone), Prolias active ingredient is denosumab. Denosumab is contraindicated in women with hypocalcaemia. Based on your dental history, your doctor can discuss with you the risks of using Prolia. A healthcare provider will give you this injection in a hospital or clinic. Sciatica is described as a shooting pain that travels from the lower back down a leg. Youll receive Prolia doses from a healthcare professional. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Having a tooth extraction while youre using Prolia may increase your risk for these side effects. Throw away a prefilled syringe after one use, even if there is still medicine left inside. Prolia comes as a solution thats given as an injection under your skin. Prolia and Evenity are both biologic medications, but Prolia contains the active drug denosumab, while Evenity contains the active drug romosozumab-aqqg. Your doctor or health care professional may order blood tests and other tests to see how you are doing. Theyre commonly used to treat osteoporosis. For instance: Both Prolia and Forteo are given as injections under your skin. Your doctor or pharmacist can tell you more about the potential side effects of Prolia and ways to reduce them. While you are using Prolia, you should not receive Xgeva, another brand of denosumab. Do not reuse a needle or syringe. Prolia may cause several side effects. Some examples are atorvastatin (Lipitor) and rosuvastatin (Crestor). (2022). If you have serious side effects from Prolia, call your doctor right away. Personalize this study to your gender and age, Arthrotec and Alanine Aminotransferase Increased, Capecitabine and Lumigan drug interaction, Cyramza and Gastrointestinal Stoma Necrosis, Simponi Aria and Pennsaid drug interaction, Docetaxel and Infection In An Immunocompromised Host, Ketorolac Tromethamine and Bladder Obstruction, Roxicodone and Caspofungin Acetate drug interaction, Ginkgo and Nitrofurantoin drug interaction. Below are answers to some commonly asked questions about Prolia. It is created by eHealthMe based on reports of 8,432 people who take Prolia and Calcium from the FDA, and is updated regularly. Check with your doctor if you have more questions about these drugs. No, weight gain wasnt reported as a side effect of Prolia in clinical trials. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. It is based on denosumab and calcium (the active ingredients of Prolia and Calcium, respectively), and Prolia and Calcium (the brand names). Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. WebNow that Im taking Prolia, do I still need calcium and vitamin D? Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Prolia is injected under the skin. It could harm the unborn baby or cause birth defects. They may help you identify other possible causes or suggest ways to help manage hair loss. Your healthcare professional might talk to you about taking a calcium or vitamin D supplement, although generally its better to get enough of each from your diet. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. If youve been diagnosed with osteoporosis, your doctor may discuss Prolia with you. Prolia contains the active drug denosumab, while Fosamax contains the active drug alendronate. A healthcare provider will give you this injection. There arent any studies that have compared these two drugs to each other. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.) The drug attaches to the RANK protein and helps prevent osteoclasts from breaking down bone. Boniva contains the active drug ibandronate, but Prolia contains the active drug denosumab. Mild side effects can occur with Prolia use. Keep out of the reach of children and pets. These lists dont include all possible side effects. Do not treat yourself. If your dizziness doesnt go away or becomes severe, talk with your doctor. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. Prolia is a medicine that may affect the ability of your body to fight infections. Continue reading, Yes, Prolia does appear to weaken your immune system. Brush and floss your teeth regularly while receiving this medication. You should not breastfeed while using this medicine. Medically reviewed by Sanjai Sinha, MD. Call your doctor for medical advice about side effects. So your healthcare provider will likely ask you to take calcium and vitamin D supplements if youre not taking them already. Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. The drug could cause your calcium level to drop too low. Prolia pregnancy and breastfeeding warnings. Heres some information on pregnancy, breastfeeding, and Prolia use. It is important not to miss your dose. A severe jawbone problem called osteonecrosis has rarely been reported with Prolia. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh. If you miss a dose of Prolia, you should receive your injection as soon as you can. American Dental Association (ADA) recommendations say that tooth extractions are allowable if needed during Prolia treatment, if both you and your dentist agree. Theres no information available to know whether Prolia is passed into breast milk or if its safe to take while breastfeeding. WebProlia is used to treat osteoporosis in women after menopause and in men, and in people Before you start Prolia treatment, your doctor will examine the inside of your mouth. Learn strategies you can use today. Your dentist may have you use a chlorhexidine mouth rinse before and after surgery to reduce your risk for jaw-related side effects. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. These medications have different active ingredients and they belong to different groups of drugs. If you receive Prolia, you should not receive XGEVA. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or. This makes your bones weak and increases your risk for bone fractures or breaks. Some reports may have incomplete information. Your doctor can discuss with you how to manage side effects and whether youll need to stop taking Prolia due to side effects. They may be able to help you identify the cause. Learn more about your health after menopause. The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Also tell them if you smoke, drink alcohol, or use illegal drugs. This lowers your risk for bone fractures. To prevent osteoporotic fractures, combined calcium and vitamin D supplementation is recommended at the correct dosage (1,0001,200 mg calcium and 800 IU of vitamin D per day). Supplementation should be targeted on vulnerable groups such as elderly and institutionalised people, patients with osteoporosis and individuals on glucocorticoids. Numerous trials have shown that calcium and vitamin D supplementation is effective and safe. In particular, no increased cardiovascular risk was observed. Your risk for infection with Prolia may be higher if you have a weakened immune system. The study uses data from the FDA. Symptoms may include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work. What osteoporosis medications are there, and what side effects do they have? Prolia also carries a warning about hypocalcemia, which is a low level of Brush and floss your teeth regularly. Osteoporosis is a condition that causes your bones to become thin and weak. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. * Approximation only. In rare cases, your doctor may have you self-inject Prolia at home. Prolia isnt approved to treat osteopenia or arthritis. Be sure to read this information carefully each time. Protect from light and do not freeze. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. No, Prolia isnt a bisphosphonate. Terms of Use. Call your doctor or health care professional if you are unable to keep an appointment. Treating any mouth or dental problems early is the best way to help prevent serious dental complications. Adults over age 50 should not exceed 2,000 mg total per day. Your side effects from Prolia may also vary depending on your gender. Studies have found that Prolia is generally safe and effective to treat osteoporosis and certain types of bone loss. Its recommended that calcium and vitamin D supplements be taken Serious side effects that have been reported and their symptoms include: * To learn more, see Does Prolia cause long-term side effects? in the FAQs about the side effects of Prolia section below. Other studies have examined the risk of damage to jaw tissue with the use of bisphosphonates, one type of medication commonly used to treat osteoporosis. They can tell you more about benefits and risks of Prolia and Forteo. Serious infections may occur during treatment with Prolia. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Yes, if recommended by your doctor, you can stop taking Prolia.

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